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Article

Lack of protection from HIV infection by the mutant HIV coreceptor CCR5 in intravenously HIV infected hemophilia patients.

Immunobiology - 1 Feb 1998

Malo A, Rommel F, Bogner J, Gruber R, Schramm W, Goebel F D, Riethmüller G, Wank R

Abstract excerpt

The CCR5 chemokine receptor is an important coreceptor for macrophage-tropic HIV strains. Homozygous carriers of the mutated CCR5 receptor with a 32 bp deletion (delta 32-CCR5) are highly protected against HIV infection. A protective effect has also been described for heterozygous individuals car...

Read the complete abstract on PubMed

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Share to CCR5 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9562872
DOI: 10.1016/S0171-2985(98)80055-7

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9562872-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Lack of protection from HIV infection by the mutant HIV coreceptor CCR5 in intravenously HIV infected hemophilia patients.PMID 9562872Read ↗

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Do chemokines play a role in HIV-1 heterosexual transmission? Susceptibility to HIV infection.Semantic proximity Read ↗

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Multiple nonfunctional alleles of CCR5 are frequent in various human populations.Semantic proximity Read ↗

Chemokine receptor CCR5 genotype influences the kinetics of human immunodeficiency virus type 1 infection in human PBL-SCID mice.Semantic proximity Read ↗

Heterozygous defect in HIV-1 coreceptor CCR5 and chemokine production.Semantic proximity Read ↗

A 32-bp deletion within the CCR5 locus protects against transmission of parenterally acquired human immunodeficiency virus but does not affect progression to AIDS-defining illness.Semantic proximity Read ↗

The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.Semantic proximity Read ↗

Limited protective effect of the CCR5Delta32/CCR5Delta32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus.Semantic proximity Read ↗

Inheritance pattern of mutant human immunodeficiency virus type 1 coreceptor gene CCR5 in an Indian family.Semantic proximity Read ↗

New CCR5 variants associated with reduced HIV coreceptor function in southeast Asia.Semantic proximity Read ↗

Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele.Semantic proximity Read ↗

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