Article
A 32-bp deletion within the CCR5 locus protects against transmission of parenterally acquired human immunodeficiency virus but does not affect progression to AIDS-defining illness.
The Journal of infectious diseases - 1 Oct 1998
Wilkinson D A, Operskalski E A, Busch M P, Mosley J W, Koup R A
Abstract excerpt
The beta-chemokine receptor CCR5 is required as a coreceptor by non-syncytium-inducing (NSI) strains of human immunodeficiency virus type 1 (HIV-1). NSI viruses predominate early during an infection and are thought to be important for the transmission of HIV-1. The importance of CCR5 during paren...
Topics
- Acquired Immunodeficiency Syndrome
- Alleles
- Base Sequence
- Blood Coagulation Factors
- Cohort Studies
- Gene Frequency
- HIV Infections
- Heterozygote
- Homozygote
- Humans
- Infusions, Parenteral
- Mutation
- Receptors, CCR5
- Sequence Deletion