Article
Protection against parenteral HIV-1 infection by homozygous deletion in the C-C chemokine receptor 5 gene.
AIDS (London, England) - 18 Jun 1999
Kupfer B, Kaiser R, Brackmann H H, Effenberger W, Rockstroh J K, Matz B, Schneweis K E
Abstract excerpt
OBJECTIVES: To investigate the role of the CC chemokine receptor 5 (CCR5) for parenteral transmission of HIV-1. DESIGN: The prevalence of the delta32 deletion within the CCR5 gene was determined in a cohort of 207 patients, who had received documented amounts of non-antibody-tested and non-inactivated clotting factor concentrate. METHODS: Chromosomal DNA of haemophiliacs was isolated from whole blood. A portion...
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