Article
CCR5 genotype and plasma beta-chemokine concentration of Brazilian HIV-infected individuals.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Nov 2002
Mikawa A Y, Tagliavini S A, Costa P I
Abstract excerpt
The 32-bp deletion in the HIV-1 co-receptor CCR5 confers a high degree of resistance to HIV-1 infection in homozygous individuals for the deleted allele and partial protection against HIV-1 during disease progression in heterozygotes. Natural ligands for CCR5, MIP-1alpha, MIP-1beta and RANTES, have been shown to inhibit HIV replication in CD4+ T cells. In the present study, we examined the CCR5 genotype by PCR...
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