Article
Heterozygous defect in HIV-1 coreceptor CCR5 and chemokine production.
Cytokine - 1 Jan 1999
Yang J Y, Togni M, Widmer U
Abstract excerpt
CC chemokine receptor 5 (CCR5) is a cell entry cofactor for macrophage-tropic isolates of human immunodeficiency virus 1 (HIV-1). An inactive CCR5 allele with a 32-nucleotide deletion (CCR5Delta32) has been described that confers resistance to HIV-1 infection in homozygotes and slows the rate of progression to AIDS in heterozygotes. We found the allele CCR5Delta32 to be not rare in 399 Swiss blood donors with a...
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