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Article

Reactivation and mutagenesis of UV irradiated lambda phage in bacteria treated with platinum (II) compounds.

Biochimie - 1 Jan 2000

Alazard R J, Germanier M

Abstract excerpt

Treatment of wild type Escherichia coli with cis -Pt(NH3)2Cl2 increased the survival and frequency of clear plaques formation of lambda phage damaged by UV radiation. The reactivation process was present in an uvrA mutant and abolished in a lexA host. Trans-Pt(NH3)2Cl2 and [Pt(dien) Cl]Cl (dien = 2HN-CH2-CH2NH-CH2-CH2-NH2) which, inhibited DNA synthesis less than the cis isomer or not at all, respectively,...

Topics

Bacteriophage lambda
Cisplatin
DNA Replication
Escherichia coli
Mutation
Ultraviolet Rays
Viral Plaque Assay

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 6215950
DOI: 10.1016/s0300-9084(82)80099-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6215950-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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