Article
An antagonistic IL-4 mutant prevents type I allergy in the mouse: inhibition of the IL-4/IL-13 receptor system completely abrogates humoral immune response to allergen and development of allergic symptoms in vivo.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1998
Grunewald S M, Werthmann A, Schnarr B, Klein C E, Bröcker E B, Mohrs M, Brombacher F, Sebald W, Duschl A
Abstract excerpt
We have analyzed in vivo effects of the murine IL-4 mutant Q116D/Y119D (QY), which forms unproductive complexes with IL-4Ralpha and is an antagonist for IL-4 and IL-13 in vitro. Treatment of BALB/c mice with QY during immunization with OVA completely inhibited synthesis of OVA-specific IgE and IgG1. BALB/c-derived knockout mice lacking either IL-4 or IL-4Ralpha also did not develop specific IgE or IgG1, but...
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