Article
γδ T cells affect IL-4 production and B-cell tolerance.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2015
Huang Yafei, Heiser Ryan A, Detanico Thiago O, Getahun Andrew, Kirchenbaum Greg A, Casper Tamara L, Aydintug M Kemal, Carding Simon R, Ikuta Koichi, Huang Hua, Cambier John C, Wysocki Lawrence J, O'Brien Rebecca L, Born Willi K
Abstract excerpt
γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells. One strain with a partial γδ deficiency that increases IgE antibodies also displayed increases in IL-4-producing T cells (both residual γδ T cells and αβ T cells) and in...
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