Generation and analysis of interleukin-4 deficient mice.

doi:10.1126/science.1948049

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Article

Generation and analysis of interleukin-4 deficient mice.

Science (New York, N.Y.) - 1 Nov 1991

Kühn R, Rajewsky K, Müller W

Abstract excerpt

Interleukin-4 (IL-4) promotes the growth and differentiation of many hematopoietic cells in vitro; in particular, it directs the immunoglobulin (Ig) class switch to IgG1 and IgE. Mice homozygous for a mutation that inactivates the IL-4 gene were generated to test the requirement for IL-4 in vivo. In the mutant mice T and B cell development was normal, but the serum levels of IgG1 and IgE were strongly reduced....

Topics

Aging
Alleles
Animals
B-Lymphocytes
Blotting, Southern
Chromosome Deletion
Concanavalin A
DNA
Female
Interleukin-4
Lymph Nodes
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Mutant Strains

Restriction Mapping

Spleen

Source

Open in PubMed

Identifiers

PMID: 1948049
DOI: 10.1126/science.1948049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1948049-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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