Article
Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma.
The Journal of allergy and clinical immunology - 1 Jun 2003
Hahn Christian, Teufel Martin, Herz Udo, Renz Harald, Erb Klaus J, Wohlleben Gisela, Bröcker Eva B, Duschl Albert, Sebald Walter, Grunewald Susanne M
Abstract excerpt
BACKGROUND: IL-4 and IL-13 are considered as key regulators for the development of atopic disease. OBJECTIVE: This study addresses the therapeutic potential of an IL-4/IL-13 inhibitor on the basis of a mutated IL-4 variant (Q116D, Y119D) during allergic sensitization and in established disease in a murine asthma model with persistent airway pathologic condition. METHODS: BALB/c mice were sensitized with ovalbumin...
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