Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite Substrains

1 May 1999

Abstract excerpt

Using genetically pure BALB/c mice deficient in IL-4 (IL-4-/-) or IL-4 receptor alpha-chain (IL-4Ralpha-/-), we have observed different disease outcomes to Leishmania major infection depending on the parasite substrain. Infection with L. major LV39 caused progressive, nonhealing ulcers and uncontrolled parasite growth in both IL-4-/- and IL-4Ralpha-/- mice. In contrast, infection with L. major IR173 was partially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parasites and Host Interactions
Share to Research on Leishmaniasis Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10229856
DOI: 10.4049/jimmunol.162.10.6132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite SubstrainsPMID 10229856Read ↗

The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major.Semantic proximity Read ↗

IL-4-deficient Balb/c mice resist infection with Leishmania major.Semantic proximity Read ↗

Despite increased CD4+Foxp3+ cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4+Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility.Semantic proximity Read ↗

The use of the murine model of infection with Leishmania major to reveal the antagonistic effects that IL-4 can exert on T helper cell development and demonstrate that these opposite effects depend upon the nature of the cells targeted for IL-4 signaling.Semantic proximity Read ↗

Setting in motion the immune mechanisms underlying genetically determined resistance and susceptibility to infection with Leishmania major.Semantic proximity Read ↗

Infection of C57BL/10ScCr and C57BL/10ScNCr mice withLeishmania majorreveals a role for Toll-like receptor 4 in the control of parasite replicationSemantic proximity Read ↗

An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infectionSemantic proximity Read ↗

In BALB/c Mice, IL-4 Production During the Initial Phase of Infection with Leishmania major Is Necessary and Sufficient to Instruct Th2 Cell Development Resulting in Progressive DiseaseSemantic proximity Read ↗

IL-13 is a susceptibility factor for Leishmania major infection.Semantic proximity Read ↗

IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Rα Signaling via T CellsSemantic proximity Read ↗

BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling.Semantic proximity Read ↗

IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.