Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif.

The Journal of allergy and clinical immunology - 1 May 2010

Tachdjian Raffi, Al Khatib Shadi, Schwinglshackl Andreas, Kim Hong Sook, Chen Andrew, Blasioli Julie, Mathias Clinton, Kim Hye Young, Umetsu Dale T, Oettgen Hans C, Chatila Talal A

Abstract excerpt

BACKGROUND: Signaling by IL-4 and IL-13 through the IL-4 receptor alpha chain (IL-4Ralpha) plays a critical role in the pathology of allergic diseases. The IL-4Ralpha is endowed with an immunoreceptor tyrosine-based inhibitory motif (ITIM) centered on tyrosine 709 (Y709) in the cytoplasmic domain that binds a number of regulatory phosphatases. The function of the ITIM in the in vivo regulation of IL-4 receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Inflammation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-13

Share to Interleukin-4

Share to Receptors, Cell Surface

Share to Respiratory Hypersensitivity

Share to STAT6 Transcription Factor

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 20392476
DOI: 10.1016/j.jaci.2010.01.054
PMCID: PMC2889905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif.PMID 20392476Read ↗

Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation.Semantic proximity Read ↗

The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production.Semantic proximity Read ↗

The Interleukin-7 Receptor Signaling Pathway and Its Perturbation in Immunodeficiency, Autoimmune Disease and Lymphoid Malignancy.Semantic proximity Read ↗

Allergy-Driven Alternative Splicing of IL-13 Receptor α2 Yields Distinct Membrane and Soluble FormsSemantic proximity Read ↗

The extracellular and transmembrane domains of the γC and interleukin (IL)-13 receptor α1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13.Semantic proximity Read ↗

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.Semantic proximity Read ↗

Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2Semantic proximity Read ↗

IL-4 receptor mutations.Semantic proximity Read ↗

Differential roles for IL-4Rα and IL-13Rα1 in immune cell infiltration and epithelial remodeling in experimental eosinophilic gastritisSemantic proximity Read ↗

Genetic variants of IL-13 signalling and human asthma and atopy.Semantic proximity Read ↗

The R576 IL-4 receptor alpha allele correlates with asthma severity.Semantic proximity Read ↗

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.