Article
Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy.
The Journal of allergy and clinical immunology - 1 Jun 2017
Freidl Raphaela, Gstoettner Antonia, Baranyi Ulrike, Swoboda Ines, Stolz Frank, Focke-Tejkl Margarete, Wekerle Thomas, van Ree Ronald, Valenta Rudolf, Linhart Birgit
Abstract excerpt
BACKGROUND: Fish is a frequent elicitor of severe IgE-mediated allergic reactions. Beside avoidance, there is currently no allergen-specific therapy available. Hypoallergenic variants of the major fish allergen, parvalbumin, for specific immunotherapy based on mutation of the 2 calcium-binding sites have been developed. OBJECTIVES: This study sought to establish a mouse model of fish allergy resembling human...
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