Article
Defective expression of p56lck in an infant with severe combined immunodeficiency.
The Journal of clinical investigation - 15 Jul 1998
Goldman F D, Ballas Z K, Schutte B C, Kemp J, Hollenback C, Noraz N, Taylor N
Abstract excerpt
Severe combined immune deficiency (SCID) is a heterogeneous disorder characterized by profound defects in cellular and humoral immunity. We report here an infant with clinical and laboratory features of SCID and selective CD4 lymphopenia and lack of CD28 expression on CD8(+) T cells. T cells from...
Topics
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- CD4-CD8 Ratio
- CD4-Positive T-Lymphocytes
- Cell Division
- Exons
- Humans
- Infant
- Lectins, C-Type
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Lymphopenia
- Male
- Phenotype
- Phosphorylation