Article
Ig gene sequences in the study of clonality.
Pathologie-biologie - 1 Feb 1999
Bakkus M H
Abstract excerpt
Investigations of normal and neoplastic B cells are being channelled into new directions by recent work on immunoglobulin variable region genes. Assembling of heavy and light chain genes introduces enormous heterogeneity into the third complementarity determining regions (CDR3s) of immunoglobulin...
Topics
- Base Sequence
- Blotting, Southern
- Clone Cells
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Class Switching
- Molecular Sequence Data
- Mutation
- Neoplasm, Residual
- Polymerase Chain Reaction