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Article

Multiple myeloma: new evidence and insights from the immunoglobulin heavy chain gene and phenotypes.

Leukemia & lymphoma - 1 Nov 1995

Takishita M, Kosaka M

Abstract excerpt

DNA analysis of the Ig genes has been utilized to delineate the stages of differentiation of normal and malignant B-lineage cells, since the mechanisms involved in V(D)J recombination, somatic hypermutations, and class switch are developmentally regulated. Somatic mutations which result in amino acid substitutions are observed frequently in the Ig variable region genes in multiple myeloma (MM), but there is no...

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PMID: 8590838
DOI: 10.3109/10428199509112196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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