Article
[Rearrangement of immunoglobulin light chain and heavy chain constant region genes in multiple myeloma].
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 1992
Maruyama F, Ino T, Miyazaki H, Nomura T, Shinkai K, Wakita M, Kojima H, Sobue R, Okamoto M, Matui T
Abstract excerpt
We analysed immunoglobulin (Ig) gene rearrangements in 28 patients with multiple myeloma by Southern hybridization method. We used 5 probes which cover C kappa and kappa de loci of Ig light chain kappa gene, and JH, 5'S mu and S gamma 3 loci of Ig heavy chain gene. In 11 out of 12 patients with kappa-producing myeloma, DNA rearrangements were observed using C kappa probe. Among them, kappa de region was...
Topics
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Genotype
- Humans
- Immunoglobulin Constant Regions
- Multiple Myeloma