Article
The nature of polymorphism of the HLA class I non-coding regions and their contribution to the diversification of HLA.
Hereditas - 1 Jan 1997
Blasczyk R, Kotsch K, Wehling J
Abstract excerpt
The sequence database of HLA class I genes is mainly derived from mRNA analysis. Little is known about the non-coding sequences of the different class I alleles. In this study we have determined the sequence of the 1st through 3rd introns of the majority of HLA-A and -B alleles. The few published...
Topics
- Alleles
- Cell Line
- CpG Islands
- DNA Mutational Analysis
- DNA, Superhelical
- Evolution, Molecular
- Gene Conversion
- Genes, MHC Class I
- Genetic Variation
- HLA-A Antigens
- HLA-B Antigens
- Humans
- Introns
- Nucleic Acid Conformation
- Polymorphism, Genetic
- Sequence Homology, Nucleic Acid