Article
The nature of polymorphism of the HLA class I non-coding regions and their contribution to the diversification of HLA.
Hereditas - 1 Jan 1997
Blasczyk R, Kotsch K, Wehling J
Abstract excerpt
The sequence database of HLA class I genes is mainly derived from mRNA analysis. Little is known about the non-coding sequences of the different class I alleles. In this study we have determined the sequence of the 1st through 3rd introns of the majority of HLA-A and -B alleles. The few published sequences emerged to contain substantial errors. The introns turned out to be highly polymorphic with a variability of...
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