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Locus specificity of polymorphic alleles and evolution by a birth-and-death process in mammalian MHC genes.

Molecular biology and evolution - 1 Feb 1999

Gu X, Nei M

Abstract excerpt

We have conducted an extensive phylogenetic analysis of polymorphic alleles from human and mouse major histocompatibility complex (MHC) class I and class II genes. The phylogenetic tree obtained for 212 complete human class I allele sequences (HLA-A, -B, and -C) has shown that all alleles from the same locus form a single cluster, which is highly supported by bootstrap values, except for one HLA-B allele...

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Identifiers

PMID: 10028282
DOI: 10.1093/oxfordjournals.molbev.a026097

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