Article
The diversity of the HLA class I introns reflects the serological relationship of the coding regions.
Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine - 1 Jan 1997
Blasczyk R, Wehling J, Kotsch K, Salama A
Abstract excerpt
The introduction of PCR-based HLA typing techniques has uncovered that the HLA system is much more variable than it has been expected from the conventional typing methods. More and more new alleles are detected which are not characterized by new sequence motifs, but by new combinations of already existing sequence motifs. This variability, reflecting the immunological necessity to have the greatest capacity for...
Topics
- Cell Line
- Genetic Variation
- HLA-A Antigens
- HLA-B Antigens
- Histocompatibility Antigens Class I
- Histocompatibility Testing
- Humans
- Introns
- Pedigree
- Phylogeny
- Polymerase Chain Reaction