Article
HLA population genetics.
Bailliere's clinical endocrinology and metabolism - 1 Jun 1991
Thomson G
Abstract excerpt
The HLA system has been extensively studied from an evolutionary perspective. The region contains a number of closely linked genes whose products control a variety of functions concerned with the regulation of immune responses. In addition, the genetic predisposition to over 40 diseases maps to this region. A number of observations indicate that strong selection is acting on the HLA region, including its...
Topics
- Alleles
- Animals
- Genetic Predisposition to Disease
- Genetic Variation
- Genetics, Population
- HLA Antigens
- Humans
- Major Histocompatibility Complex
- Pan troglodytes