Article
Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos.
Mechanisms of development - 1 Sept 2002
Jiang Xiaobing, Choudhary Bibha, Merki Esther, Chien Kenneth R, Maxson Robert E, Sucov Henry M
Abstract excerpt
Mouse embryos lacking the retinoic acid (RA) receptors RARalpha1 and RARbeta suffer from a failure to properly septate (divide) the early outflow tract of the heart into distinct aortic and pulmonary channels, a phenotype termed persistent truncus arteriosus. This phenotype is associated with a failure in the development of the cardiac neural crest cell lineage, which normally forms the aorticopulmonary septum....
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