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Article

The importance of C4A null genes in Norwegian patients with systemic lupus erythematosus.

Scandinavian journal of immunology - 1 Nov 1995

Skarsvåg S

Abstract excerpt

C4A null genes were determined by RFLP (Taq I) and SSO-probing on PCR-amplified C4-DNA in 51 Scandinavian patients with systemic lupus erythematosus (SLE) and 124 controls. Associations of the alleles DRB1*0301, DQA1*0501, DQB1*0201 had previously been found in this SLE group, as well as increased frequency of HLA-DRB1 and -DQ homozygosity. The frequency of the allele C4A*Q0 was increased among the patients (RR =...

Topics

Adolescent
Adult
Aged
Alleles
Base Sequence
Complement C4a
DNA Primers
Female
Genes, MHC Class II
Humans
Lupus Erythematosus, Systemic
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 7481564
DOI: 10.1111/j.1365-3083.1995.tb03698.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7481564-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The importance of C4A null genes in Norwegian patients with systemic lupus erythematosus.PMID 7481564Read ↗

Relative contributions of HLA-DQA and complement C4A loci in determining susceptibility to systemic lupus erythematosus.Semantic proximity Read ↗

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Major histocompatibility complex (MHC) complement deficiency, ancestral haplotypes and systemic lupus erythematosus (SLE): C4 deficiency explains some but not all of the influence of the MHC.Semantic proximity Read ↗

Deficiency of C4A is a genetic determinant of systemic lupus erythematosus in three ethnic groups.Semantic proximity Read ↗

HLA-class II alleles and C4 null genes in Greeks with systemic lupus erythematosus.Semantic proximity Read ↗

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Impact of Homozygous C4A Deficiency on Clinical Presentation of Systemic Lupus Erythematosus.Semantic proximity Read ↗

Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus.Semantic proximity Read ↗

A study of the association of HLA DR, DQ, and complement C4 alleles with systemic lupus erythematosus in Iceland.Semantic proximity Read ↗

C4A and C4B null alleles are genetic markers of different types of systemic sclerosis in Japanese patients.Semantic proximity Read ↗

Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).Semantic proximity Read ↗

C4 null alleles in a Swedish population.Semantic proximity Read ↗

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