Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A molecular and serologic analysis of the major histocompatibility complex and complement component C4 in systemic sclerosis.

Arthritis and rheumatism - 1 Jul 1993

Briggs D, Stephens C, Vaughan R, Welsh K, Black C

Abstract excerpt

OBJECTIVE: To investigate the contributions of the major histocompatibility complex (MHC) and C4 alleles to systemic sclerosis (SSc), and to pulmonary fibrosis and autoantibody expression in SSc, by analysis at the DNA level. METHODS: One hundred fifteen patients with SSc were tested serologically for alleles of the class I MHC loci, and were tested for class II alleles (DRB, DQA, and DPB) by a combination of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class II

Share to HLA-DQ Antigens

Share to HLA-DR Antigens

Share to Major Histocompatibility Complex

Share to Molecular Sequence Data

Source

Identifiers

PMID: 8318041
DOI: 10.1002/art.1780360711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A molecular and serologic analysis of the major histocompatibility complex and complement component C4 in systemic sclerosis.PMID 8318041Read ↗

Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes.Semantic proximity Read ↗

Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls.Semantic proximity Read ↗

Immunogenetics of systemic sclerosis.Semantic proximity Read ↗

HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry.Semantic proximity Read ↗

Clinical correlates, serum autoantibodies and the role of the major histocompatibility complex in French Canadian and non-French Canadian Caucasians with SLE.Semantic proximity Read ↗

Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis.Semantic proximity Read ↗

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosisSemantic proximity Read ↗

C4A and C4B null alleles are genetic markers of different types of systemic sclerosis in Japanese patients.Semantic proximity Read ↗

Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis.Semantic proximity Read ↗

Molecular heterogeneity of second and fourth components of complement and their genes in systemic sclerosis and association of HLA alleles A1, B8 and DR3 with limited and DR5 with diffuse systemic sclerosis.Semantic proximity Read ↗

Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma.Semantic proximity Read ↗

Analysis of Class II human leucocyte antigens in Italian and Spanish systemic sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.