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Article

Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants

7 Jun 2001

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 11423991
DOI: 10.1038/sj.onc.1204457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutantsPMID 11423991Read ↗

p53 mutations isolated in yeast based on loss of transcription factor activity: similarities and differences from p53 mutations detected in human tumors.Semantic proximity Read ↗

Mammalian p53 can function as a transcription factor in yeastSemantic proximity Read ↗

Transactivation by temperature-dependent p53 mutants in yeast and human cells.Semantic proximity Read ↗

Identification of partial loss of function p53 gene mutations utilizing a yeast-based functional assay.Semantic proximity Read ↗

Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.Semantic proximity Read ↗

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay.Semantic proximity Read ↗

Screening the p53 status of human cell lines using a yeast functional assay.Semantic proximity Read ↗

Functional analysis of p53 tumor suppressor in yeast.Semantic proximity Read ↗

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations.Semantic proximity Read ↗

Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo.Semantic proximity Read ↗

Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells.Semantic proximity Read ↗

Mutation detection by a two-hybrid assay.Semantic proximity Read ↗

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