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Article

Overexpression of EGFR and c‐erbB2 causes enhanced cell migration in human breast cancer cells and NIH3T3 fibroblasts

20 Mar 1998

Abstract excerpt

Overexpression of EGFR and c-erbB2 frequently occurs in human breast cancers, correlating with poor prognosis. Here we show that overexpression of EGFR and c-erbB2 in cell lines increases cell migration, an important step in metastasis formation. The effect of EGFR on migration is dependent on the addition of EGF to the cells. In contrast, c-erbB2 seems to act independently of its ligand in these assays....

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Identifiers

PMID: 9541025
DOI: 10.1016/s0014-5793(98)00224-5

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Source receipt: pubmed, retrieved 7 Sept 2026.

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