Article
c-erbB-2/EGFR as dominant heterodimerization partners determine a motogenic phenotype in human breast cancer cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 1999
Brandt B H, Roetger A, Dittmar T, Nikolai G, Seeling M, Merschjann A, Nofer J R, Dehmer-Möller G, Junker R, Assmann G, Zaenker K S
Abstract excerpt
Separate mechanisms for oncogenesis and metastasis have been postulated. We show here that prolonged and invasive cell migration, a key mechanism in cancer metastasis, is linked to c-erbB-2 signaling. Cell lines with c-erbB-2 and EGFR expression and transphosphorylation activity display a high transendothelial invasiveness in an endothelial-extracellular matrix model mimicking a capillary vessel wall in vitro....
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