Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C-Src activation by ErbB2 leads to attachment-independent growth of human breast epithelial cells.

Biochemical and biophysical research communications - 8 Sept 1998

Sheffield L G

Abstract excerpt

Nontumorigenic human mammary epithelial cells (184.A1 line) were stably transfected with ErbB2 or with Ha-Ras. Transformation with ErbB2, but not ras, resulted in a 5-6 fold increase in c-src activity without affecting c-src content of cells. Similar activation of c-src by ErbB2 was also observed...

Topics

Animals
Breast
Cell Division
Cells, Cultured
Humans
Mice
Phenotype
Protein Binding
Proto-Oncogene Proteins pp60(c-src)
src-Family Kinases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9735325
DOI: 10.1006/bbrc.1998.9214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9735325-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C-Src activation by ErbB2 leads to attachment-independent growth of human breast epithelial cells.PMID 9735325Read ↗

ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells.Semantic proximity Read ↗

c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential.Semantic proximity Read ↗

New model of ErbB-2 over-expression in human mammary luminal epithelial cellsSemantic proximity Read ↗

Overexpression of EGFR and c‐erbB2 causes enhanced cell migration in human breast cancer cells and NIH3T3 fibroblastsSemantic proximity Read ↗

The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation.Semantic proximity Read ↗

Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation.Semantic proximity Read ↗

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer.Semantic proximity Read ↗

erbB-2 Overexpression in Human Mammary Epithelial Cells Confers Growth Factor Independence*Semantic proximity Read ↗

Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2.Semantic proximity Read ↗

c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy.Semantic proximity Read ↗

Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines.Semantic proximity Read ↗

Transforming and oncogenic potential of activated c-Ha-ras in three immortalized human breast epithelial cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.