Article
Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation.
Oncogene - 30 Jul 1998
Giani C, Casalini P, Pupa S M, De Vecchi R, Ardini E, Colnaghi M I, Giordano A, Ménard S
Abstract excerpt
c-erbB-2, a member of the tyrosine kinase oncogene family, is overexpressed in about 30% of human breast tumors where it correlates with poor prognosis. In vitro studies have suggested that increased expression of the receptor plays an important role in malignant progression. To better understand...
Topics
- Adenocarcinoma
- Breast Neoplasms
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Differentiation
- Cell Division
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Down-Regulation
- Enzyme Activation
- Estradiol
- Estrogens
- Female
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Humans
- Phenotype
- Phosphorylation
- Receptor, ErbB-2