Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation.

Oncogene - 30 Jul 1998

Giani C, Casalini P, Pupa S M, De Vecchi R, Ardini E, Colnaghi M I, Giordano A, Ménard S

Abstract excerpt

c-erbB-2, a member of the tyrosine kinase oncogene family, is overexpressed in about 30% of human breast tumors where it correlates with poor prognosis. In vitro studies have suggested that increased expression of the receptor plays an important role in malignant progression. To better understand the direct effects of p185HER2 overexpression, a human c-erbB-2 expression vector was transfected into the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Division

Share to Enzyme Activation

Share to Gene Expression

Share to Gene Expression Regulation, Neoplastic

Share to Phenotype

Share to Phosphorylation

Source

Identifiers

PMID: 9696035
DOI: 10.1038/sj.onc.1201954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation.PMID 9696035Read ↗

New model of ErbB-2 over-expression in human mammary luminal epithelial cellsSemantic proximity Read ↗

Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cellsSemantic proximity Read ↗

erbB-2 Overexpression in Human Mammary Epithelial Cells Confers Growth Factor Independence*Semantic proximity Read ↗

Role of HER2 gene overexpression in breast carcinomaSemantic proximity Read ↗

Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells.Semantic proximity Read ↗

Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines.Semantic proximity Read ↗

ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells.Semantic proximity Read ↗

Role of steroid hormone and growth factor receptors and proto-oncogenes in the behavior of human mammary epithelial cancer cells in vitro.Semantic proximity Read ↗

Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulatorSemantic proximity Read ↗

Insulin-like growth factor-II overexpression in MCF-7 cells induces phenotypic changes associated with malignant progression.Semantic proximity Read ↗

The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factorsSemantic proximity Read ↗

C-Src activation by ErbB2 leads to attachment-independent growth of human breast epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.