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Article

Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.

Cell - 11 Aug 2006

Guo Wenjun, Pylayeva Yuliya, Pepe Angela, Yoshioka Toshiaki, Muller William J, Inghirami Giorgio, Giancotti Filippo G

Abstract excerpt

Amplification of the ErbB2 locus, which encodes a receptor tyrosine kinase, is common in aggressive breast tumors and correlates with poor prognosis. The mechanisms underlying ErbB2-mediated breast carcinoma progression remain incompletely defined. To examine the role of the signaling and cell-adhesion receptor beta 4 integrin during ErbB2-mediated tumorigenesis, we introduced a targeted deletion of the beta 4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to JNK Mitogen-Activated Protein Kinases

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Source

Identifiers

PMID: 16901783
DOI: 10.1016/j.cell.2006.05.047

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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