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Article

c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy.

Oncology reports - 1 Nov 2007

Zhang Yan, Pu Xiaoyun, Shi Ming, Chen Liyong, Qian Lu, Song Yuhua, Yuan Guogang, Zhang Hao, Yu Ming, Hu Meiru, Shen Beifen, Guo Ning

Abstract excerpt

Human breast cancer cell line SKBR3 expresses high level of the ErbB2 molecule, which has been associated with poor prognosis of breast cancer. Elevated ErbB2 functions as a transactivating co-receptor and promotes the formation of ErbB2 containing heterodimers, which are more mitogenic and transforming, and have a higher ligand affinity and signaling potency by virtue of the potent latent kinase activity of...

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PMID: 17914574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy.PMID 17914574Read ↗

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C-Src activation by ErbB2 leads to attachment-independent growth of human breast epithelial cells.Semantic proximity Read ↗

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