Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.

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Article

Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.

Oncogene - 1 Jul 1992

Müller O, Frech M, Gideon P, Wittinghofer A, Schwarz M

Abstract excerpt

The intrinsic GTPase activity of the cellular protein p21ras is strongly increased by two cytosolic proteins, the GTPase-activating protein (GAP) produced by the neurofibromatosis type 1 gene (NF1-GAP) and a GAP of 120 kDa molecular mass (p120-GAP). The GAP-mediated stimulation of p21ras GTPase a...

Topics

Animals
Cytosol
GTP Phosphohydrolases
GTPase-Activating Proteins
Genes, ras
Kinetics
Liver
Liver Neoplasms, Experimental
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mutation
Neoplasm Proteins
Proteins
Substrate Specificity
ras GTPase-Activating Proteins

Source

Open in PubMed

Identifiers

PMID: 1620552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1620552-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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