Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene.

Gastroenterology - 1 Jul 2004

Schreiber Franz S, Deramaudt Therese B, Brunner Thomas B, Boretti Michael I, Gooch Keith J, Stoffers Doris A, Bernhard Eric J, Rustgi Anil K

Abstract excerpt

BACKGROUND & AIMS: The Ki-RAS oncogene is altered in pancreatic ductal neoplasms. Pancreatic ductal cells (PDCs) were purified from cytokeratin 19 (K19)-Ki-RAS(G12V) transgenic mice and control littermates to identify properties of Ki-Ras activation in a cell-type-specific context. Because Ki-RAS mutation has prognostic significance in patients treated with radiation, we studied the influence of Ki-RAS status on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Cell Division

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Genes, ras

Share to Models, Animal

Share to Pancreatic Ducts

Share to Protein Prenylation

Share to Radiotherapy

Source

Identifiers

PMID: 15236190
DOI: 10.1053/j.gastro.2004.03.058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene.PMID 15236190Read ↗

Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells.Semantic proximity Read ↗

Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.Semantic proximity Read ↗

Pancreatic Cancer Cell Radiation Survival and Prenyltransferase Inhibition: The Role of K-RasSemantic proximity Read ↗

In vitro Modeling of Human Pancreatic Duct Epithelial Cell Transformation Defines Gene Expression Changes Induced by K- ras Oncogenic Activation in Pancreatic CarcinogenesisSemantic proximity Read ↗

Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas.Semantic proximity Read ↗

K-Ras Promotes Growth Transformation and Invasion of Immortalized Human Pancreatic Cells by Raf and Phosphatidylinositol 3-Kinase SignalingSemantic proximity Read ↗

Transforming growth factor alpha activates Ha-Ras in human pancreatic cancer cells with Ki-ras mutations.Semantic proximity Read ↗

Molecular alterations associated with improved survival in pancreatic cancer patients treated with radiation or chemotherapy.Semantic proximity Read ↗

The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.Semantic proximity Read ↗

K-Ras-Independent Effects of the Farnesyl Transferase Inhibitor L-744,832 on Cyclin B1/Cdc2 Kinase Activity, G2/M Cell Cycle Progression and Apoptosis in Human Pancreatic Ductal Adenocarcinoma CellSemantic proximity Read ↗

Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells.Semantic proximity Read ↗

p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.