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Article

Thapsigargin, a weak skin tumor promoter, alters the growth and differentiation of mouse keratinocytes in culture.

Carcinogenesis - 1 Apr 1996

Lowry D T, Li L, Hennings H

Abstract excerpt

Thapsigargin (Tg), applied twice weekly to the backs of CD-1 mice initiated with 7,12-dimethylbenz[a]anthracene, promoted papillomas on the skin of approximately 50% of the mice. Tg alone induced papillomas in 10% of the mice. Although Tg and 12-O-tetradecanoylphorbol-13-acetate (TPA) are synergi...

Topics

Animals
Calcium
Carcinogens
Cell Differentiation
Cell Division
Cells, Cultured
Drug Synergism
Female
Hyperplasia
Keratinocytes
Mice
Phenotype
Skin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin Neoplasms

Terpenes

Tetradecanoylphorbol Acetate

Thapsigargin

Source

Identifiers

PMID: 8625480
DOI: 10.1093/carcin/17.4.699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8625480-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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