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Article

Coupling termination of transcription to messenger RNA maturation in yeast.

Science (New York, N.Y.) - 10 Apr 1998

Birse C E, Minvielle-Sebastia L, Lee B A, Keller W, Proudfoot N J

Abstract excerpt

The direct association between messenger RNA (mRNA) 3'-end processing and the termination of transcription was established for the CYC1 gene of Saccharomyces cerevisiae. The mutation of factors involved in the initial cleavage of the primary transcript at the poly(A) site (RNA14, RNA15, and PCF11) disrupted transcription termination at the 3' end of the CYC1 gene. In contrast, the mutation of factors involved in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9535662
DOI: 10.1126/science.280.5361.298

Genes

CYC1
PCF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coupling termination of transcription to messenger RNA maturation in yeast.PMID 9535662Read ↗

The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation.Semantic proximity Read ↗

Coupling of termination, 3' processing, and mRNA export.Semantic proximity Read ↗

An essential role for Clp1 in assembly of polyadenylation complex CF IA and Pol II transcription termination.Semantic proximity Read ↗

RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3'-end processing factor.Semantic proximity Read ↗

A role for CF1A 3' end processing complex in promoter-associated transcription.Semantic proximity Read ↗

The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation.Semantic proximity Read ↗

Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response.Semantic proximity Read ↗

The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site.Semantic proximity Read ↗

Distinct roles of two Yth1p domains in 3'-end cleavage and polyadenylation of yeast pre-mRNAs.Semantic proximity Read ↗

Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1.Semantic proximity Read ↗

Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination.Semantic proximity Read ↗

Signals that produce 3' termini in CYC1 mRNA of the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

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