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Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response.

Genetics - 7 Feb 2024

Graber Joel H, Hoskinson Derick, Liu Huiyun, Kaczmarek Michaels Katarzyna, Benson Peter S, Maki Nathaniel J, Wilson Christian L, McGrath Caleb, Puleo Franco, Pearson Erika, Kuehner Jason N, Moore Claire

Abstract excerpt

The Pcf11 protein is an essential subunit of the large complex that cleaves and polyadenylates eukaryotic mRNA precursor. It has also been functionally linked to gene-looping, termination of RNA Polymerase II (Pol II) transcripts, and mRNA export. We have examined a poorly characterized but conserved domain (amino acids 142-225) of the Saccharomyces cerevisiae Pcf11 and found that while it is not needed for mRNA...

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PMID: 37967370
DOI: 10.1093/genetics/iyad199
PMCID: PMC10847720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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