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Article

Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1.

Genes & development - 15 Apr 2003

He Xiaoyuan, Khan Asad U, Cheng Hailing, Pappas Donald L, Hampsey Michael, Moore Claire L

Abstract excerpt

Transcription and processing of pre-mRNA are coupled events. By using a combination of biochemical, molecular, and genetic methods, we have found that the phylogenetically conserved transcription factor Ssu72 is a component of the cleavage/polyadenylation factor (CPF) of Saccharomyces cerevisiae. Our results demonstrate that Ssu72 is required for 3' end cleavage of pre-mRNA but is dispensable for poly(A) addition...

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Share to Chromatography, Affinity
Share to mRNA Cleavage and Polyadenylation Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoprotein Phosphatases

Share to Poly A

Share to RNA Polymerase II

Share to RNA Processing, Post-Transcriptional

Share to Terminator Regions, Genetic

Share to Transcription Factor TFIIB

Source

Open in PubMed Open full text

Identifiers

PMID: 12704082
DOI: 10.1101/gad.1075203
PMCID: PMC196040

Genes

SUB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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