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Article

An essential role for Clp1 in assembly of polyadenylation complex CF IA and Pol II transcription termination.

Nucleic acids research - 1 Feb 2012

Haddad Raphaël, Maurice Frédérique, Viphakone Nicolas, Voisinet-Hakil Florence, Fribourg Sébastien, Minvielle-Sébastia Lionel

Abstract excerpt

Polyadenylation is a co-transcriptional process that modifies mRNA 3'-ends in eukaryotes. In yeast, CF IA and CPF constitute the core 3'-end maturation complex. CF IA comprises Rna14p, Rna15p, Pcf11p and Clp1p. CF IA interacts with the C-terminal domain of RNA Pol II largest subunit via Pcf11p which links pre-mRNA 3'-end processing to transcription termination. Here, we analysed the role of Clp1p in 3'...

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Identifiers

PMID: 21993300
DOI: 10.1093/nar/gkr800
PMCID: PMC3273802

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Source receipt: pubmed, retrieved 7 Sept 2026.

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An essential role for Clp1 in assembly of polyadenylation complex CF IA and Pol II transcription termination.PMID 21993300Read ↗

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