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Article

rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development.

Development (Cambridge, England) - 1 Jun 1999

Guichard A, Biehs B, Sturtevant M A, Wickline L, Chacko J, Howard K, Bier E

Abstract excerpt

Genes of the ventrolateral group in Drosophila are dedicated to developmental regulation of Egfr signaling in multiple processes including wing vein development. Among these genes, Egfr encodes the Drosophila EGF-Receptor, spitz (spi) and vein (vn) encode EGF-related ligands, and rhomboid (rho) and Star (S) encode membrane proteins. In this study, we show that rho-mediated hyperactivation of the EGFR/MAPK pathway...

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Source

Identifiers

PMID: 10331978
DOI: 10.1242/dev.126.12.2663

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development.PMID 10331978Read ↗

Analysis of the genetic hierarchy guiding wing vein development in Drosophila.Semantic proximity Read ↗

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Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins.Semantic proximity Read ↗

Groucho restricts rhomboid expression and couples EGFR activation with R8 selection during Drosophila photoreceptor differentiation.Semantic proximity Read ↗

Alternate functions of the single-minded and rhomboid genes in development of the Drosophila ventral neuroectoderm.Semantic proximity Read ↗

EGFR signaling is required for the differentiation and maintenance of neural progenitors along the dorsal midline of the Drosophila embryonic head.Semantic proximity Read ↗

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Blistered: a gene required for vein/intervein formation in wings of Drosophila.Semantic proximity Read ↗

The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor.Semantic proximity Read ↗

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.Semantic proximity Read ↗

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