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Article

Computational analysis of EGFR inhibition by Argos.

Developmental biology - 15 Aug 2005

Reeves Gregory T, Kalifa Rachel, Klein Daryl E, Lemmon Mark A, Shvartsman Stanislav Y

Abstract excerpt

Argos, a secreted inhibitor of the Drosophila epidermal growth factor receptor, and the only known secreted receptor tyrosine kinase inhibitor, acts by sequestering the EGFR ligand Spitz. We use computational modeling to show that this biochemically-determined mechanism of Argos action can explain available genetic data for EGFR/Spitz/Argos interactions in vivo. We find that efficient Spitz sequestration by Argos...

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Identifiers

PMID: 15982648
DOI: 10.1016/j.ydbio.2005.05.013

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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