Article
Antimorphic goosecoids.
Development (Cambridge, England) - 1 Apr 1998
Ferreiro B, Artinger M, Cho K, Niehrs C
Abstract excerpt
goosecoid (gsc) is a homeobox gene expressed in the Spemann organizer that has been implicated in vertebrate axis formation. Here antimorphic gscs are described. One antimorphic gsc (MTgsc) was fortuitously created by adding 5 myc epitopes to the N terminus of gsc. The other antimorph (VP16gsc) contains the transcriptional activation domain of VP16. mRNA injection of either antimorph inhibits dorsal gastrulation...
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