Article
Association of genetic defects in primary resected lung adenocarcinoma revealed by targeted allelic imbalance analysis.
American journal of respiratory cell and molecular biology - 1 Oct 2002
Cave-Riant Florence, Cuillerier Benoit, Beau-Faller Michèle, Martinet Nadine, Alla François, Bronner Christian, Schneider Anne, Oudet Pierre, Gaub Marie Pierre
Abstract excerpt
Genetic mechanisms underlying origin and progression of lung cancer are still poorly understood, despite the numerous studies which identified many genomic alterations. Using polymorphic microsatellites, allelic imbalances have been frequently found at loci such as 3p, 5q, 8p, 9p and 9q, 11p and 11q, and 17q without either histologic specificity or prognosis value. We report allelotyping results in 54 cases (50...
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