Article
Quantitative DNA pooling to increase the efficiency of linkage analysis in autosomal dominant disease.
Human genetics - 1 Feb 1998
Damji K F, Gallione C J, Allingham R R, Slotterbeck B, Guttmacher A E, Pasyk K A, Vance J M, Pericak-Vance M A, Speer M C, Marchuk D A
Abstract excerpt
DNA pooling is an efficient method to rapidly perform genome-wide linkage scans in autosomal recessive diseases in inbred populations where affected individuals are likely to be homozygous for alleles near the disease gene locus. We wanted to examine whether this approach would detect linkage in autosomal dominant (AD) disorders where affected individuals may share one allele identical by descent at loci tightly...
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