Article
A simple method for analyzing microsatellite allele image patterns generated from DNA pools and its application to allelic association studies.
American journal of human genetics - 1 May 1998
Daniels J, Holmans P, Williams N, Turic D, McGuffin P, Plomin R, Owen M J
Abstract excerpt
Allelic association studies provide the most powerful method for locating genes of small effect contributing to complex diseases and traits. However, in outbred populations, allelic association is usually maintained only over distances of <=1 cM. Therefore, systematic searches over large regions are costly. Here we present a method involving DNA pooling that can be used as a rapid preliminary screen for allelic...
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