Cl- transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC.

doi:10.1111/j.1469-7793.1998.825bp.x

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Article

Cl- transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC.

The Journal of physiology - 1 May 1998

Briel M, Greger R, Kunzelmann K

Abstract excerpt

1. Epithelial Na+ channels (ENaCs) are inhibited by the cystic fibrosis transmembrane conductance regulator (CFTR) when CFTR is activated by protein kinase A. Since cAMP-dependent activation of CFTR Cl- conductance is defective in cystic fibrosis (CF), ENaC currents are not inhibited by CFTR. Thi...

Topics

1-Methyl-3-isobutylxanthine
Amiloride
Animals
Calcium
Calcium Channel Blockers
Chlorides
Cystic Fibrosis Transmembrane Conductance Regulator
Cytosol
Diuretics
Down-Regulation
Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epithelial Cells

Epithelial Sodium Channels

Female

Gene Expression

Humans

Mutation

Oocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 9518736
DOI: 10.1111/j.1469-7793.1998.825bp.x
PMCID: PMC2230925

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9518736-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Cl- transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC.PMID 9518736Read ↗

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