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Article

Cl- interference with the epithelial Na+ channel ENaC.

The Journal of biological chemistry - 9 Sept 2005

Bachhuber Tanja, König Jens, Voelcker Thilo, Mürle Bettina, Schreiber Rainer, Kunzelmann Karl

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is a protein kinase A and ATP-regulated Cl- channel that also controls the activity of other membrane transport proteins, such as the epithelial Na+ channel ENaC. Previous studies demonstrated that cytosolic domains of ENaC are critical for down-regulation of ENaC by CFTR, whereas others suggested a role of cytosolic Cl- ions. We therefore examined in...

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Source

Identifiers

PMID: 16027156
DOI: 10.1074/jbc.M504347200

Genes

CFTR
CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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