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Article

The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa.

BMC physiology - 24 Sept 2012

Tucker Torry A, Fortenberry James A, Zsembery Akos, Schwiebert Lisa M, Schwiebert Erik M

Abstract excerpt

BACKGROUND: Rescue or correction of CFTR function in native epithelia is the ultimate goal of CF therapeutics development. Wild-type (WT) CFTR introduction and replacement is also of particular interest. Such therapies may be complicated by possible CFTR self-assembly into an oligomer or multimer. RESULTS: Surprisingly, functional CFTR assays in native airway epithelia showed that the most common CFTR mutant,...

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Source

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Identifiers

PMID: 22999299
DOI: 10.1186/1472-6793-12-12
PMCID: PMC3507716

Genes

CFTR
CALU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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