Regulation of CFTR chloride channel macroscopic conductance by extracellular bicarbonate.

Abstract excerpt

The CFTR contributes to Cl⁻ and HCO₃⁻ transport across epithelial cell apical membranes. The extracellular face of CFTR is exposed to varying concentrations of Cl⁻ and HCO₃⁻ in epithelial tissues, and there is evidence that CFTR is sensitive to changes in extracellular anion concentrations. Here we present functional evidence that extracellular Cl⁻ and HCO₃⁻ regulate anion conduction in open CFTR channels. Using...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bicarbonates
• Share to Biological Transport, Active