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Article

Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.

American journal of physiology. Cell physiology - 1 Apr 2007

Suaud Laurence, Yan Wusheng, Carattino Marcelo D, Robay Amal, Kleyman Thomas R, Rubenstein Ronald C

Abstract excerpt

Regulatory interactions of the cystic fibrosis transmembrane conductance regulator (CFTR) and the epithelial Na(+) channel (ENaC) are readily apparent in Xenopus oocytes. However, the mechanism underlying these interactions remains controversial. CFTR's first nucleotide binding fold (NBD-1) may be important in these interactions, as dysfunctional CFTRs containing mutations within NBD-1, such as DeltaF508 and...

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Source

Identifiers

PMID: 17182731
DOI: 10.1152/ajpcell.00064.2006

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.PMID 17182731Read ↗

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Cl- interference with the epithelial Na+ channel ENaC.Semantic proximity Read ↗

Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

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