Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.

doi:10.1152/ajpcell.00064.2006

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Article

Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.

American journal of physiology. Cell physiology - 1 Apr 2007

Suaud Laurence, Yan Wusheng, Carattino Marcelo D, Robay Amal, Kleyman Thomas R, Rubenstein Ronald C

Abstract excerpt

Regulatory interactions of the cystic fibrosis transmembrane conductance regulator (CFTR) and the epithelial Na(+) channel (ENaC) are readily apparent in Xenopus oocytes. However, the mechanism underlying these interactions remains controversial. CFTR's first nucleotide binding fold (NBD-1) may be important in these interactions, as dysfunctional CFTRs containing mutations within NBD-1, such as DeltaF508 and...

Topics

1-Methyl-3-isobutylxanthine
Animals
Chlorides
Colforsin
Cystic Fibrosis Transmembrane Conductance Regulator
Epithelial Sodium Channel Blockers
Epithelial Sodium Channels
Female
Humans
In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ion Transport

Mice

Mutation

Oocytes

Patch-Clamp Techniques

Protein Binding

Xenopus laevis

Source

Open in PubMed

Identifiers

PMID: 17182731
DOI: 10.1152/ajpcell.00064.2006

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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