Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes.

doi:10.1126/science.1722350

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes.

Science (New York, N.Y.) - 20 Dec 1991

Drumm M L, Wilkinson D J, Smit L S, Worrell R T, Strong T V, Frizzell R A, Dawson D C, Collins F S

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is associated with expression of a chloride conductance that is defective in cystic fibrosis (CF). Xenopus oocytes injected with RNA coding for CFTR that contained mutations in the first nucleotide binding fold (NBF1) expressed chloride currents in response to raising adenosine 3',5'-monophosphate (cAMP) with forskolin and 3-isobutyl-1-methylxanthine...

Topics

1-Methyl-3-isobutylxanthine
Animals
Chloride Channels
Chlorides
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Genetic Variation
Genotype
Humans
Ion Channels
Membrane Potentials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Microinjections

Mutation

Oocytes

RNA

Transcription, Genetic

Xenopus

Source

Open in PubMed

Identifiers

PMID: 1722350
DOI: 10.1126/science.1722350

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1722350-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes.PMID 1722350Read ↗

Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.Semantic proximity Read ↗

Abnormal regulatory interactions of I148T-CFTR and the epithelial Na+ channel in Xenopus oocytes.Semantic proximity Read ↗

Two cystic fibrosis transmembrane conductance regulator mutations have different effects on both pulmonary phenotype and regulation of outwardly rectified chloride currents.Semantic proximity Read ↗

Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes.Semantic proximity Read ↗

Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.Semantic proximity Read ↗

Mutations in the nucleotide binding domain 1 signature motif region rescue processing and functional defects of cystic fibrosis transmembrane conductance regulator delta f508.Semantic proximity Read ↗

Function of Xenopus Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl- Channels and Use of Human-Xenopus Chimeras to Investigate the Pore Properties of CFTRSemantic proximity Read ↗

Cl- transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC.Semantic proximity Read ↗

Aquaporin 3 cloned from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance regulatorSemantic proximity Read ↗

Inhibition of protein kinase CK2 closes the CFTR Cl channel, but has no effect on the cystic fibrosis mutant deltaF508-CFTR.Semantic proximity Read ↗

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells.Semantic proximity Read ↗

Effects of cystic fibrosis and congenital bilateral absence of the vas deferens-associated mutations on cystic fibrosis transmembrane conductance regulator-mediated regulation of separate channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.